70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke
نویسندگان
چکیده
منابع مشابه
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke
The 70-kDa inducible heat shock protein (Hsp70) is known to protect the brain from stressful stimuli, including stroke. Hsp70 also interferes with cell death pathways, such as apoptosis. Precise protective mechanisms are many, and protection by Hsp70 might lead to the identification of new therapeutic targets. To this end, we applied a proteomic approach to mice overexpressing Hsp70 (Hsp70 tran...
متن کامل70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
BACKGROUND AND PURPOSE The 70-kDa heat shock protein (Hsp70) protects brain cells in models of cerebral ischemia. Proteomic screening of mice subjected to middle cerebral artery occlusion identified dynamin as a major downregulated protein in Hsp70-overexpressing mice (Hsp70 transgenic mice). Dynamin-1 is expressed in neurons and participates in neurotransmission, but also transports the death ...
متن کاملThe production of molecular clones of Toxoplasma gondii-derived heat shock protein 70 kDa
Toxoplasmosis is a common and widespread infection in humans and many other species of warm–blooded animals. Toxoplasma gondii-derived heat shock protein 70 (Hsp70) may play an important role in the virulence of Toxoplasma gondii (T. gondii). In the present study, T. gondii Hsp70 was amplified by polymerase chain reaction (PCR) from the DNA of the T. gondiitachyzoite RH strain through the use o...
متن کاملmolecular characterization of a 70 kda heat shock protein (hsp70) gene in entamoeba dispar
amebiasis caused by entamoeba histolytica is still mentioned as one of the major health problems in tropical and subtropical areas. e. histolytica has recently been redescribed as two distinct species; e. histolytica and e. dispar. in the present study, we characterized the 70 kda heat shock protein (hsp70) of e. dispar at molecular level and compared it with that of e. histolytica. with these ...
متن کاملthe production of molecular clones of toxoplasma gondii-derived heat shock protein 70 kda
toxoplasmosis is a common and widespread infection in humans and many other species of warm–blooded animals. toxoplasma gondii-derived heat shock protein 70 (hsp70) may play an important role in the virulence of toxoplasma gondii (t. gondii). in the present study, t. gondii hsp70 was amplified by polymerase chain reaction (pcr) from the dna of the t. gondiitachyzoite rh strain through the use o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stroke
سال: 2016
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.116.012763